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KMID : 1143520220100040096
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Journal of Korean Society of Oral Health Science
2022 Volume.10 No. 4 p.96 ~ p.103
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HS-1200 Induces Apoptosis and Inhibits Epithelial-Mesenchymal Transition in Oral Squamous Carcinoma
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Kim Young-Jin
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Abstract
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Objectives: HS-1200 is a synthetic derivative of bile acid that has been proven to induce apoptosis in various types of cancer cells. However, whether HS-1200 inhibits metastasis in oral cancer has not yet been determined. Therefore, this study aims to evaluate the anti-cancer effect of HS-1200 through the inhibition of EMT in human oral squamous cell carcinoma (OSCC).
Methods: The cytotoxicity effect of HS-1200 was assessed using an MTT assay. Furthermore, the cell migration and invasion ratios were obtained using a wound-healing assay and a transwell migration assay. The expressions of protein and mRNA levels were measured using a western blot analysis and real-time PCR.
Results: HS-1200 was observed to inhibit the metastasis of cancer cells by regulating EMT in SCC-25 and HSC-3 cells.
Conclusions: HS-1200 exhibits considerable potential as a treatment for OSCC.
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KEYWORD
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Apoptosis, EMT, HS-1200, Oral Cancer, OSCC
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